IndraLab

Statements

USP4 inhibits Interferon. 4 / 4
| 4
reach
"Overall, these data suggest that USP4 suppresses IRF3 activation and the IFN response, at least partially, by deubiquitinating the K63-linked polyubiquitination of IRF3 either through TRAF6 or by dire[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
reach
"These results suggest that USP4 inhibits the IFN response by suppressing the nuclear localization of IRF3.It has been demonstrated that K63-linked polyubiquitination enhances the activation of IRF3, w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
reach
"In the current study, we demonstrated that USP4 suppresses the IFN response and antigen presentation process in CRC cells, suggesting that USP4 negatively regulates cytosolic PRR-mediated signaling an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
reach
"In addition, USP4 suppressed IFN response and antigen presentation process, thus impeding the antitumor immune response in CRC cells and a syngeneic mouse model."
38556105