IndraLab

Statements

(R)-lipoic acid inhibits CASP1. 4 / 4
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"Additionally, LA inhibited the production of IL-1 beta and IL-18, as well as caspase-1 maturation, by inhibition of NLRP3 inflammasome activation in LPS and ATP stimulated cells."
30452073
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"Pretreatment of LA and AH significantly reduced caspase-1 activation without displaying host cell cytotoxicity in activated human mast cells."
31368553
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"PMA plus A23187 stimulation up-regulated caspase-1 activity in HMC-1 cells; however, this up-regulated caspase-1 activity was down-regulated by LA."
30011850
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"The results of the present study revealed that LA inhibited the activation of caspase-1 (Figure 4); therefore, it can be assumed that LA inhibits TSLP production and mRNA expression through blocking of caspase-1 activation in mast cells."
30011850