IndraLab

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KCNK2 inhibits MCF2L2. 3 / 3
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"58 Studies have also shown that administration of OXP can induce hyperexcitability of neurons in mice, reduce the expression of potassium ion channel, double‐porous potassium ion channel TREK‐1, and protein TRAAK, and increase the hyperpolarized cyclic nucleosides in DRG neurons and acid‐gated channels, causing neurotoxicity."
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"The upregulation of TREK-1 channel in DRG might suppress the excitability of DRG neurons and play a protective role in DO rats."
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"Importantly, administration of RNE28 did not induce constipation, respiratory depression, sedation, or rewarding effects.Loucif et al. [78] reported that 4,4'-(hexafluoroisopro- pylidene) bis (p-phenyleneoxy) dianiline (GI-530159), a selective activator of TREK-1 and TREK-2 with EC of 0.9 μM in HEK293 cells, could reduce the firing frequency of DRG neurons by activating TREK channels, and lead to a small hyperpolarization of the RMP at 1 μM."
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