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Mice activates USP13. 3 / 3
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"In contrast, the fasting blood glucose levels in USP13 overexpression mice were significantly reduced after being fed HFD for 16 weeks when compared with the control group (Fig. 3B)."
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"The Rosa mice subjected to AAV8-TBG-Cre injection were used to specifically overexpress USP13 in hepatocytes, followed by a 24-weeks administration with HFHC diet (Fig. 4A) (hereunder named as Hep OE HFHC)."
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"Accordingly, the Rosa mice injected with AAV-TBG-Cre vectors were used to overexpress USP13 abundance only in hepatocytes, followed by a HFMCD fodder feeding for 8 weeks (Fig. 7A) (hereafter referred to as Hep OE HFMCD)."
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