IndraLab

Statements

UCHL3 activates Carcinogenesis. 5 / 5
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"In conclusion, our findings suggest that UCHL3 promotion of RCC tumorigenesis may be achieved through inactivating CD8 T cells."
39034372
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"Regulating biological functions, UCHL3 promoted GSC proliferation, tumorigenesis, self-renewal, and radioresistance in a POLD4-dependent manner.The degradation of POLD4 by ubiquitin ligases in response to DNA damage and during cell cycle progression plays a less prominent role in normal cells [43], while with increasing insights into the complex mechanisms of DNA damage repair, POLD4 is projected to play an increasingly important role."
38829550
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"Our data suggested that UCHL3 depletion reduced bladder tumorigenesis in a xenograft model and that this effect was at least partially dependent on CTNNB1 stabilization."
37740194
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"Uchl3 deficiency leads to inhibited BBN-induced bladder tumorigenesis in mice."
37740194
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"In summary, it is suggested that UCHL3 may contribute to liver tumorigenesis and may be a useful prognostic biomarker in HCC."
36969045