IndraLab

Statements

KCNH2 activates IKr. 6 / 6
| 1 5
eidos
"IKr is mediated by Kv11.1 , a VGIC encoded by the KCNH2 gene ( also known as the human ether-a-go-go related gene , hERG ) ."
| PMC
reach
"Functional gain-of-function mutations of KCNQ1 or KCNH2 enhance the outward flow of ions (IKr, IKs), which accelerates the repolarization process."
33817101
reach
"The elementary properties of HERG are unknown, and as a test of the hypothesis that HERG produces IKr, we compared their elementary properties."
8921803
reach
"Human ether-a-go-go-related gene (hERG) channels conduct the rapidly activating current IKr; KCNQ1 and KCNE1 channels conduct the slowly activating current IKs; and Kv1.5 channels conduct an ultrarapid activating current IKur."
27261821
reach
"The N588K mutation in the KCNH2 gene causes a gain of function of IKr, and shortens the action potential duration and the QT interval."
25335996
reach
"Potassium channels encoded by human ether-a-go-go-related gene (hERG) mediate the cardiac rapid delayed rectifier K (+) current (IKr), which participates in ventricular repolarization and has a protective role against unwanted premature stimuli late in repolarization and early in diastole."
25318749