IndraLab

Statements


KCNH2 activates IKr. 3 / 3
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"Functional gain-of-function mutations of KCNQ1 or KCNH2 enhance the outward flow of ions (IKr, IKs), which accelerates the repolarization process."

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"The elementary properties of HERG are unknown, and as a test of the hypothesis that HERG produces IKr, we compared their elementary properties."

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"The N588K mutation in the KCNH2 gene causes a gain of function of IKr, and shortens the action potential duration and the QT interval."