IndraLab

Statements

USP8 binds CHMP4B. 5 / 5
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sparser
"Association of UBPY with HD-PTP involves UBPY interacting with HD-PTP-bound CHMP4B, as well as additional interaction(s) between UBPY and HD-PTP."
23477725
reach
"In a sequence of competitive interactions, STAM2, which binds to HD-PTP/PTPN23 via two interactions, is replaced by CHMP4B and USP8 binding to both STAM2 and HD-PTP/PTPN23."
31845722
sparser
"We investigated in more detail how UBPY bound HD-PTP Bro1-V. We focused on the N-terminal MIT domain of UBPY, which also binds CHMP4B, because this is essential for recruiting UBPY to endosomes and su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23477725
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"First, the coordinated recruitment of CHMP4B and UBPY to HD-PTP would bring about exchange reactions that disrupt both modes of STAM2 binding to HD-PTP."
23477725
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"Based on these studies, we propose a model whereby the concerted recruitment of CHMP4B and UBPY to HD-PTP and the engagement of UBPY by STAM2 displaces ESCRT-0 from HD-PTP, deubiquitinates EGFR, and releases ESCRT-0 from cargo in favor of ESCRT-III."
23477725