IndraLab

Statements

Glycine betaine inhibits NLRP3. 6 / 6
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"Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior."
36339940
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"Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-kappaB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis."
29881379
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"Additionally, emerging evidences have demonstrated that betaine enhances/restores Na -K -ATPase activity which maintains low Na and high K cell homeostasis (62, 63), and similarly, reduces K efflux (64); therefore, we speculate that betaine suppresses NLRP3 activation through maintaining cytosolic normal K levels (Figure 1E)."
30515160
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"Betaine Inhibits NLRP3 Inflammasome Activation."
29881379
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"Betaine inhibited AβO-induced neuroinflammation in microglia by inhibiting the activation of the NLRP3 inflammasome and NF-κB, which supports further evaluation of betaine as a potential effective modulator for AD."
37334594
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"Recent studies have demonstrated that betaine treatment can significantly inhibit NLRP3 inflammasome related proteins, such as NLRP3 and mature caspase-1, and the levels of pro inflammatory cytokines, including IL-1beta, in a dose independent manner in fructose induced NAFLD models."
29881379