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Glycine betaine inhibits NLRP3. 15 / 15
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"These results suggest that betaine regulates, at the cellular and molecular level, the association between FOXO1 and the NLRP3 inflammasome, suggesting a new target for the treatment of diabetes.In co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior."
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"Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-kappaB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis."
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"Natural betaine and Huangkui capsule have been demonstrated to inhibit NF-κB/NLRP3 and to reduce the initiation of NLRP3 activation; and interventional treatment in a DN mouse model reduced urinary protein, creatinine, urea nitrogen, uric acid, glomerular mesangial hyperplasia, and renal fibrosis [38, 39]."
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"Many inflammatory diseases are associated with chronic activation of NF‐κB. 40 , 55 , 56 Multiple studies have shown that betaine can inhibit the activation of the NLRP3 inflammasome."
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"The degradation rate of NLRP3 was higher in the betaine group compared with the Hcy group, suggesting that betaine could reduce the stability of NLRP3 mRNA (Fig. 6I).3.7 Betaine reduced the NLRP3 mRNA stability in an m 6 A-YTHDF2-dependent manner."
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"Considering that betaine increased the m A modification of NLRP3 while reduced the stability of NLRP3 mRNA, we hypothesized that betaine might exert its protective effect through YTHDF2 or YTHDF3."
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"Moreover, analyzing NLRP3 mRNA levels in the presence of betaine pretreatment revealed that betaine promoted the degradation of NLRP3 in sh-NC transfected HMC3 cells, but when YTHDF2 was silenced, the promoting effect of betaine on the NLRP3 degradation was inhibited (Fig. 6P)."
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"Additionally, betaine can inhibit the NLRP3 inflammasome by enhancing IRS activity to activate PKB/Akt pathway (Zhao et al., 2018)."
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"Betaine inhibited Aβ-induced neuroinflammation in microglia by inhibiting the activation of the NLRP3 inflammasome and NF-κB (Zhang and Jia, 2023)."
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"Betaine inhibited AβO-induced neuroinflammation in microglia by inhibiting the activation of the NLRP3 inflammasome and NF-κB, which supports further evaluation of betaine as a potential effective modulator for AD."
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"Additionally, emerging evidences have demonstrated that betaine enhances/restores Na -K -ATPase activity which maintains low Na and high K cell homeostasis (62, 63), and similarly, reduces K efflux (64); therefore, we speculate that betaine suppresses NLRP3 activation through maintaining cytosolic normal K levels (Figure 1E)."
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"Betaine Inhibits NLRP3 Inflammasome Activation."
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"Recent studies have demonstrated that betaine treatment can significantly inhibit NLRP3 inflammasome related proteins, such as NLRP3 and mature caspase-1, and the levels of pro inflammatory cytokines, including IL-1beta, in a dose independent manner in fructose induced NAFLD models."
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"Furthermore, betaine treatment was found to enhance N 6 -methyladenosine (m 6 A) modification of NLRP3 mRNA, and reduced the NLRP3 mRNA stability through increasing the expression of the m 6 A reader YTH N 6 -methyladenosine RNA binding protein 2 (YTHDF2)."
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