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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

COPS6 inhibits SIRT2. 3 / 3

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"Further investigation discovered that CSN6 suppressed the expression of SIRT2 via up-regulating Nkx2.2 , a transcription suppressor of SIRT2 ."

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"Finally, our data showed that CSN6 was partially dependent on the stabilization of Nkx2.2 protein to inhibit SIRT2 and promote myocardial hypertrophy."

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"CSN6 inhibited the expression of SIRT2 , and re-expression of SIRT2 attenuated the myocardial hypertrophy caused by CSN6 overexpression ."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

COPS6 inhibits SIRT2. 3 / 3

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