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COPS6 inhibits SIRT2. 3 / 3

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"In addition, the luciferase reporter gene assay showed that CSN6 inhibited the transcription activity of SIRT2 promoter ( Fig.S3 E)."

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"CSN6 inhibited the expression of SIRT2 , and re-expression of SIRT2 attenuated the myocardial hypertrophy caused by CSN6 overexpression ."

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"Further investigation discovered that CSN6 suppressed the expression of SIRT2 via up-regulating Nkx2.2 , a transcription suppressor of SIRT2 ."

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IndraLab

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COPS6 inhibits SIRT2. 3 / 3

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