IndraLab

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ITGAV binds THBS1. 10 / 11
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sparser
"We further confirmed that TGFβ-induced THBS1 interacts with integrin receptor ITGAV, facilitating the migration and invasion of cancer cells in both in vitro and in vivo models."
39304722
sparser
"ITGAV plays an important role in cell adhesion and migration; therefore, we investigated the interaction of THBS1 with ITGAV."
39304722
sparser
"As expected, TβRI interacted with THBS1 as well as ITGAV, which is TGFβ-dependent (Fig. xref )."
39304722
sparser
"Furthermore, we employed proximity ligation assay (PLA) to investigate the interaction of THBS1 with ITGAV in a wound-healing assay."
39304722
sparser
"This showed that the interaction of THBS1 with ITGAV frequently appeared in the migratory cells toward the wound, while knockdown of TβRI prevented the formation of the migratory complex (Fig. xref )."
39304722
reach
"Besides, thrombospondin-1 (THBS1) encodes the ECM adhesive glycoprotein and binds to ITGAV to regulate focal adhesion disassembly and cell-to-matrix interactions , which was significantly enriched in extracellular matrix (GO:0031012), focal adhesion (bta04510), and ECM-receptor interaction (bta04512) in this study."
34099805
sparser
"Here, we applied gene-modified cell lines and detected the interaction of THBS1 with TβRI and ITGAV."
39304722
sparser
"As we observe that TβRI is forming a protein complex with THBS1 and ITGAV in the frontier of the migratory PC3U cells, we think it might be a way for the identified protein complex to facilitate the localization of active TGFβ close to the receptors, as both THBS1 and ITGAV can facilitate the release of active TGFβ from its latent complex."
39304722
sparser
"Notably, we found that TβRI is forming a protein complex with ITGAV and THBS1 in the front of migrating PC3U cells, thereby utilizing the matrix protein THBS1."
39304722
sparser
"Additionally, CTHRC1+ fibroblasts enhanced the migration and invasion of malignant EPC_1 through WNT5A-LRP6/FZD3 and THBS1-ITGAV interactions."
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