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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP4 inhibits TRAF6. 3 / 3

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"Overexpression of USP4 inhibits EV71 replication by stabilizing TRAF6 to activate NF-kappaB inflammatory signaling."

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"USP4 (ubiquitin specific peptidase 4) also negatively regulates TRAF6, by a mechanism that involves removal of polyubiquitin chains."

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"55 Ubiquitin specific peptidase 4 (USP4) negatively regulates TRAF6, suppressing IL-1beta-induced NF-kappaB activation by removing polyubiquitin chains on TRAF6 in a deubiquitin activity dependent manner."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP4 inhibits TRAF6. 3 / 3

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