IndraLab

Statements

USP4 inhibits TRAF6. 4 / 4
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"Overexpression of USP4 inhibits EV71 replication by stabilizing TRAF6 to activate NF-kappaB inflammatory signaling."
33681193
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"Mechanistically, USP4 can directly bind to the TRAF domain to inhibit TRAF2/TRAF6 activity through deubiquitination in an activity-dependent manner and negatively regulate IL-1β and TNF-α-induced NF-κB activation, thereby inhibiting lung cancer metastasis (46)."
36969062
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"USP4 (ubiquitin specific peptidase 4) also negatively regulates TRAF6, by a mechanism that involves removal of polyubiquitin chains."
23774844
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"55 Ubiquitin specific peptidase 4 (USP4) negatively regulates TRAF6, suppressing IL-1beta-induced NF-kappaB activation by removing polyubiquitin chains on TRAF6 in a deubiquitin activity dependent manner."
23429360