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USP8 activates SOX2. 2 / 2

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"One compound ChlA-F blocked cell invasion via inhibition of SOX2 protein by USP8-mediated SOX2 degradation in bladder cancer (98)."

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"Further studies found that ChlA-F treatment upregulated both the transcription and translation of ubiquitin specific peptidase 8 (USP8) and that the knockdown of USP8 reversed the downregulation of SOX2 resulting from ChlA-F treatment."

36465380

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IndraLab

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USP8 activates SOX2. 2 / 2

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