IndraLab

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USP8 activates cell growth. 14 / 17
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"For example, the ubiquitin-specific peptidase 8 (USP8) inhibitor DUB-IN-1 can inhibit ESCC cell growth by stimulating autophagy through p53-dependent adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) [55]."
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"USP8 was originally identified to enhance cell growth as its expression increases upon serum stimulation in cancer cells."
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"Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway."
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"DUB-IN-1 and its analogs inhibited the growth of colon and prostate cancer cells, with IC s ranging 0.5–1.5 µM. Novel USP8 inhibitors were further discovered and exhibited anticancer efficiency, and treatment with the USP8 inhibitor or siRNA targeting USP8 was reported to inhibit HER-3-positive gastric cancer cell growth [14]."
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"Knockout of USP8 Impairs Cell Growth and Induces Apoptosis in Human BC Cells."
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"In contrast, USP8 knockdown suppressed melanoma cell growth, survival and migration, and augmented the inhibitory effects of therapeutic drugs."
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"USP8 is known to enhance cell growth as its expression increases in cancer cell XREF_BIBR."
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"As USP8 silencing significantly inhibited the PCa cell growth, proliferation, and metastasis and induced apoptosis and suppressed NF-kB signal activation by decreasing EGFR and PI3K, the USP8-specific inhibitor might be a novel therapeutic target to suppress PCa cell growth, proliferation, and metastasis."
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"36 , 37 Also, USP8 enhanced the cell growth and immune escape of NSCLC by deubiquitinating of PD‐L1."
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"XREF_BIBR Ubiquitin specific peptidases (USP8) was originally identified to enhance cell growth as its expression increases upon serum stimulation in cancer cells."
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"This study also shows that USP8 overexpression promotes PCa cell growth, survival, and migration and suppresses apoptosis."
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"USP8 silencing significantly inhibits PCa cell growth, survival, and migration and promotes apoptosis by increasing cleaved Caspase 3 and cleaved Caspase 9."
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"More interestingly, knockdown of USP8 was reported to induce apoptosis of HER3-positive GC cells and reduce the cell growth or viability by arresting the cell cycle [ 56 ]."
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"Small molecule inhibitors of USP8 (HBX90,397 and HBX 90,659) have been shown to inhibit HCT116 and PC3 cell growth, and to display specificity for USP8 among a panel of cysteine proteases [XREF_BIBR]."
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