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Otilonium bromide inhibits USP28. 3 / 3
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"Since the possible binding surface revealed by the HDX-MS data for Otilonium Bromide in USP28 is spatially far from the catalytic core of the enzyme, we then conclude that Otilonium Bromide inhibits t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Otilonium Bromide (OB), which is known as an antimuscarinic and calcium channel blocker and used for the treatment of uncontrollable abdominal pain, was identified to inhibit USP28′s enzymatic activit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Besides, the Tm of USP28 negatively shifted with a value of 9.30 ℃ after the incubation with Otilonium Bromide, which indicates that the inhibitor could downregulate the thermal stability of USP28 ( F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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