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ATXN3 inhibits E2. 1 / 1

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"The temporary formation of E2, parkin, and Ataxin-3 complex contributes to the stabilization of E2 and Parkin interaction, impeding the dissociation of the uncharged E2 which can be recharged by E1, meanwhile diverting the Ub from the E2-Ub thioester conjugate onto Ataxin-3 itself, and away from parkin."

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IndraLab

Statements

ATXN3 inhibits E2. 1 / 1

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