IndraLab

Statements

ALKBH5 decreases the amount of USP22. 3 / 3
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"Because ALKBH5 KD reduced USP22 expression, we wondered whether changes in ALKBH5 levels or activity affects H2A and H2B monoubiquitylation levels."
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"Because ALKBH5 KD increased m A levels and significantly decreased USP22 mRNA steady-state levels, we performed mRNA stability analyses in scrambled siRNA and ALKBH5-silenced osteosarcoma cells."
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"In addition, deficiency of ALKBH5‐mediated m6A modification in osteosarcoma causes an increase expression of histone deubiquitinase USP22 and ubiquitin ligase RNF40, which inhibits histone H2AK199 monoubiquitination, induces the expression of genes related to DNA repair, and promotes the progression of osteosarcoma."
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