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USP1 activates CDKN1A. 2 / 2
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"Increased USP1 levels were also observed upon siRNA mediated p21 depletion (see XREF_FIG, lanes 5 and 6)."

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"Significantly, CDKN1A siRNAs restored S phase entry in USP1 deficient U2-OS cells, indicating that p21 is essential for the cell-cycle arrest induced by USP1 knockdown.If ID degradation in the absence[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"