IndraLab

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"It was also found that SAHA inhibits ZD55-TRAIL-induced upregulation of IκBα, p50, and p65, which are crucial molecules in the NF-κB pathway that regulates cellular growth and proliferation [38,39,40]."

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"But HMGB1 was required for SAHA induced suppression of NF-kappaB1."

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"SAHA treatment also decreased the basal level of NFkB activity in H-INV cells."

No evidence text available

No evidence text available

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"At the molecular level, it was found that upregulation of IkappaBalpha and the p50 and p65 subunits of nuclear factor-kappaB induced by ZD55-TRAIL, can be abrogated by SAHA treatment."