IndraLab

Statements

TNFAIP3 inhibits TRAF6. 10 / 10
1 | 3 1 5
sparser
"Some of the proteins induced include SOCS3 – which inhibits JAKs, A20- which inhibits TRAF6, ABIN-3 which inhibits NFκB, and the transcriptional regulators, Hes1 and STAT3, that suppress the synthesis of inflammatory cytokines ( xref )."
22224769
eidos
"In our study , it was proved that A20 inhibited autophagy , reduced TRAF6 expression and decreased the number of TRAP-positive osteoclasts and the areas of hydroxyapatite resorption ."
32027437
sparser
"Downstream to Toll-like receptor 4 (TLR4) and tumor necrosis factor receptor 1 (TNFR1) the A20 complex inactivates TRAF6 and RIP1, repressing the NF- κ B signaling pathway [ xref , xref ]."
26576414
reach
"The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion."
32771556
eidos
"The K63-linkage ubiquitination facilitates TRAF6 to exert ubiquitin function , while the K48-linkage ubiquitination is involved in the degradation of TRAF6.22 Therefore , this result indicates that A20 could inhibit ubiquitination of TRAF6 , and accelerate TRAF6 degradation to suppress autophagy in hPDLCs under hypoxia ."
32027437
eidos
"TRAF6 are inhibited by A20 , CYLD and OTUB2 that specially remove TRAF6 K63-linked ubiquitination ."
28744851
sparser
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
sparser
"A20 inhibits TRAF6, a molecule required for IL-17 induced NFκB and MAPK signaling ( xref )."
30543901
signor
"A20 is a deubiquitinating enzyme (dub) for lys63-linked polyubiquitinated signaling mediators such as traf6"
18164316
sparser
"A20 expression was regulated by NF-κB. In turn, increased A20 expression inhibited TRAF6 and NF-κB to reduce the subsequent inflammatory response."
34381441