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Statements

TNFAIP3 inhibits TRAF6. 8 / 9
1 | 2 2 4
eidos
"The K63-linkage ubiquitination facilitates TRAF6 to exert ubiquitin function , while the K48-linkage ubiquitination is involved in the degradation of TRAF6.22 Therefore , this result indicates that A20 could inhibit ubiquitination of TRAF6 , and accelerate TRAF6 degradation to suppress autophagy in hPDLCs under hypoxia ."
32027437
sparser
"A20 inhibits TRAF6, a molecule required for IL-17 induced NFκB and MAPK signaling ( xref )."
30543901
reach
"In the IL-17 signaling pathway, Tnfaip3, which acts as a crucial negative feedback regulator of NF-κB, could inhibit TRAF6 and thus reduce the subsequent NF-κB, contributing to redox and inflammatory homeostasis."
38057164
sparser
"Downstream to Toll-like receptor 4 (TLR4) and tumor necrosis factor receptor 1 (TNFR1) the A20 complex inactivates TRAF6 and RIP1, repressing the NF- κ B signaling pathway [ xref , xref ]."
26576414
sparser
"Some of the proteins induced include SOCS3 – which inhibits JAKs, A20- which inhibits TRAF6, ABIN-3 which inhibits NFκB, and the transcriptional regulators, Hes1 and STAT3, that suppress the synthesis of inflammatory cytokines ( xref )."
22224769
reach
"Inactivating mutations of negative regulators UBE2O and TNFAIP3, which normally inhibit TRAF6, are also observed to cause overstimulation of downstream NF-κB pathway (Miao et al., 2019)."
36818048
sparser
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
eidos
"In our study , it was proved that A20 inhibited autophagy , reduced TRAF6 expression and decreased the number of TRAP-positive osteoclasts and the areas of hydroxyapatite resorption ."
32027437