IndraLab

Statements

USP7 activates MDC1. 6 / 6
| 6
reach
"Significantly, USP7 physically interacted with and modulated the stabilization of MDC1, thereby sustaining the DDR and conferring cellular resistance to genotoxic insults [101]."
36694209
reach
"Depletion of USP7 impaired the engagement of the MRE11-RAD50-NBS1 (MRN)-MDC1 complex."
38672118
reach
"USP7 interacts with and modulates the stabilization of MDC1, 12 the MRN–MDC1 complex, CHK1, 13 CDC25A and p53, 14 and has been shown to regulate the function of the DDR and to confer cellular resistan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35760282
reach
"We demonstrate that USP7 mediated MDC1 stabilization promoted cervical cancer cell survival and conferred cellular resistance to genotoxic insults."
30179224
reach
"Given that VGLL3 and USP7 can both be recruited to DSB sites, and USP7-promoted MDC1 stabilization is potentiated by DNA damage (40), our finding suggests that VGLL3 likely has a potential to ensure a more robust MDC1-dependent signaling."
39383226
reach
"Consequently, VGLL3 depletion sensitizes cells to PARPi and DSB-causing agents.We found that knockdown of the USP7 E3 ligase TRIP12 (36) can also rescue the MDC1 reduction in VGLL3-depleted cells, in the presence or absence of USP7 depletion."
39383226