IndraLab

Statements

EIF3F decreases the amount of MYC. 4 / 4
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"Immunohistochemistry and immunoblotting showed that tumors with eIF3f KD exhibited a marked reduction in proliferation marker Ki‐67 and reduced the PHGDH, PSPH, PSAT1, and MYC expression (Figure 5E)."
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"Furthermore, eIF3f KD accelerated the turnover rate of MYC and increased the ubiquitination level of MYC (Figure 4I,J), while overexpression of eIF3f reduced the ubiquitination level of MYC in a dose‐dependent manner (Figure 4K)."
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"Interestingly, immunoblotting showed that KD of eIF3f could reduce protein level of MYC but has no impact on MYC mRNA expression level (Figure 4G–H and Figure S4B, Supporting Information)."
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"Taken together, these results indicated that GSK3β mediates PHGDH phosphorylation, which enhances the FBXW7β regulation on PHGDH ubiquitination.2.4 eIF3f Antagonizes the Ubiquitination Level of MYC, a Transcriptional Activator of PHGDH, Thereby Promoting MYC-Mediated Elevation of PHGDH."
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