IndraLab

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"In this study, genistein reduced nuclear NF-kappaBp65 compared with the DSS group in Caco-2 cells."

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"Although we failed to notice any significant difference in total NF-kappaBp65 in Caco-2 cells (P> 0.05), DSS treatment markedly enhanced nuclear NF-kappaBp65 abundance and genistein reduced nuclear NF-kappaBp65 compared with the DSS group (P < 0.05)."

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"It was found that NF-kappaB was constitutively active in two human myeloma cell lines examined and that genistein, a chemopreventive agent, down-regulated NF-kappaB in two cell lines as indicated by the electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry."

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"In the human myeloma cell lines RPMI8226 and XG, genistein downregulates the activity and expression of NF-кB, and prevents the nuclear retention of p65, one of the NF-кB proteins [14] ."