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N-(3-oxododecanoyl)-L-homoserine lactone inhibits NLRP3. 2 / 2

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"Moreover, 3-oxo-C12-HSL completely blocked the NLRP3 inflammasome activation in response to LPS and ATP stimulation."

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"Similar to pyocyanin, two P. aeruginosa autoinducers showed no effect on the AIM2 dependent caspase-1 activation triggered by poly dA : dT transfection, indicating that 3-oxo-C12-HSL could suppress NLRC4 and NLRP3 inflammasome signaling."

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IndraLab

Statements

N-(3-oxododecanoyl)-L-homoserine lactone inhibits NLRP3. 2 / 2

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