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OTUB2 activates YAP1. 17 / 17
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"OTUB2 activates YAP in VSMCs."
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"Zhang et al. [12] demonstrated that OTUB2 promoted tumor metastasis by independently activating YAP and TAZ."
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"Notably, OTUB2 deficiency also resulted in severely decreased expression of YAP/TAZ target gene signature ( Li et al., 2017 ) ( Figure 2 C), which was confirmed in qRT-PCR assays ( Figure S3 B), sugge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2 activates YAP protein by direct deubiquitination and stabilization [47]."
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"In addition, sumoylation of OTUB2, a deubiquitinase participating in the maintenance of several CSCs, enables its interaction with transcriptional regulators YAP/TAZ to activate YAP/TAZ signaling and promote cancer cell stemness (Zhang et al., 2019)."
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"Since OTUB2 modulates YAP activity and VC progression, we next sought to investigate the potential regulatory mechanisms between OTUB2 and YAP."
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"A protein half-life assay revealed that OTUB2 knockdown decreased YAP protein stability in VSMCs (Figure 5G)."
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"Conversely, OTUB2 overexpression increased the stability of YAP (Figure 5H)."
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"These observations indicate that the OTUB2-induced cancer stem cell traits might be a result of YAP/TAZ activation."
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"In the present study, we found that OTUB2-mediated YAP stabilization promotes PFKFB3 transcription, thereby accelerating VC in CKD."
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"Taken together, these results support a notion that OTUB2 activates YAP/TAZ signaling and thereby supports cancer stemness and metastasis.We investigated the molecular mechanism by which OTUB2 potenti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, increasing evidence has demonstrated that the selective inhibition of DUBs may represent an effective approach for the treatment of multiple disorders 51-52.In the present study, we found that OTUB2 knockdown or inhibition decreased YAP abundance."
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"Indeed, OTUB2-KO in MCF10A-RAS (MII) cells significantly reduced protein expression of YAP/TAZ and AXL, a downstream target of YAP/TAZ, but had no effect on YAP/TAZ mRNA levels ( Figure 3 B), suggesti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2 activates YAP in VSMCs."
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"Additionally, inhibition of the proteasome via MG132 prevented the OTUB2-mediated downregulation of the YAP protein."
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"OTUB2 promotes the progression of breast cancer by directly deubiquitinating and stabilizing YAP and TAZ to activate the YAP signalling pathway [9]."
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"OTUB2 activates YAP protein by direct deubiquitination and stabilization [ xref ]."
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