IndraLab

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CAV3 binds HCN4. 19 / 24
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"We hypothesize that Cav3 associates with HCN4 and regulates the function of HCN4 channel."
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"Similarly, EMMPRIN silenced cells showed a significant reduction in the binding of caveolin-3 and HCN4, which regulates the I (f) current, suggesting that, rather than a direct interaction, both proteins bind to EMMPRIN."
33132099
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"Several studies show interaction of CAV3 with HCN4 and disruption of caveolae with methyl-β-cyclodestrin ablates the ability of β 2-ARs to modulate HCN4 activity, supporting their co-localization at the membrane [ xref ]."
37122225
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"In addition to inhibition of the I (f) current, ivabradine may induce cardiac protection by inhibiting ECM degradation through preservation of the caveolin-3/LG and EMMPRIN complex and control heart rate by stabilizing the caveolin-3 and HCN4 complex."
33132099
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"Molecular and functional evidence of HCN4 and caveolin-3 interaction during cardiomyocyte differentiation from human embryonic stem cells."
23311301
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"A number of laboratories including ours have provided evidence that HCN4 channels are localized to caveolae based on the presence of HCN4 in low density membrane fractions along with Cav-3 as well as the specific interaction of HCN4 with Cav-3 ( xref ; xref ; xref )."
19351512
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"Several studies demonstrated that HCN channels localize to caveolae based on the presence of HCN4 in low-density membrane fractions along with Cav-3 as well as the specific interaction of HCN4 with Cav-3 ( xref ; xref ). xref reported that all HCN isoforms have a conserved caveolin-binding domain which impact both channel function and trafficking."
30538641
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"We next tested whether caveolin-3 can bind to HCN4 and EMMPRIN and found that the HCN4 and EMMPRIN complex was preserved when we silenced caveolin-3 expression, indicating a direct interaction between these 2 proteins."
33132099
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"P104L does not disrupt the association between Cav3 and HCN4."
19238754
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"A similar shift has been previously demonstrated in hESC due to a specific HCN4-Caveolin-3 interaction [ xref ], shift that can be reverted by caveolae disruption with Methyl-β-cyclodextrin or by disruption of the caveolin-binding motif of HCN4 [ xref ]."
33934225
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"The immunoprecipitation results indicated an association of HCN4 and Cav3 in the heart and in HEK293 cells."
19238754
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"We conclude that HCN4 associates with Cav3 to form a HCN4 macromolecular complex."
19238754
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"Interestingly, studies have shown that Cav3 is associated with HCN4, and affects its function [ xref ]."
27807743
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"We sought to determine whether HCN4 associates with Cav3 in the heart."
19238754
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"Caveolin 3, a protein that is localized in cardiomyocyte caveolae, forms a complex with HCN4, leading to β-adrenergic blockade [87]."
36769115
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"These results confirm that the HCN4 and Cav3 proteins may be associated with one another."
19238754
sparser
"However, it is still unknown if HCN4 associates with Cav3."
19238754
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"HCN4 interacts with caveolin-3 during cardiomyocyte development (Bosman et al., xref )."
35663267
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"Clustering of HCN channels is likely due to a specific localization of the HCN4 protein to lipid rafts due to the interaction of the HCN4 protein with caveolin-3 (see Supplementary Fig. 2 for a repres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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