IndraLab

Statements

USP9X activates ITCH. 5 / 5
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"It was previously reported that USP9X knock-down induces ITCH down-regulation in BxPC3 cells cultured in agar suspension, but not in monolayer [XREF_BIBR]."
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"The USP9x deubiquitylating enzyme has been shown to promote ITCH stability by counteracting auto-ubiquitylation [XREF_BIBR]."
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"ITCH and AIP4 activity was activated by the deubiquitinases USP8 and USP9X, as demonstrated by RNA interference."
27203743
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"We demonstrate that the expression of the deubiquitinase USP9X, which activates ITCH stability, is increased in 9F7-F11-treated pancreatic cancer cells."
27203743
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"Loss of Usp9x led to decreased Itch and Numb levels, and a concomitant increase in levels of the Notch intracellular domain as well as, increased expression of the Notch target gene Hes5."
28808228