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"Pretreatment with IFNβ led to increased levels of IRF3 activation by dsDNA90 treatment in all cell sublines.IFNβ pretreatment but not dsDNA90 increased USP18 levels in parental FTE-194 cells and UBA7-null cells, but not in ISG15-null cells (Fig. 3), likely reflecting the importance of free ISG15 in stabilizing USP18."