IndraLab

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"Inhibition of IKK-beta, in addition to inhibition of PTP1B, in mice treated with the SA compounds, could be a possible mechanism of the compound 's biological response including the resistance to diet induced weight gain and improvement in blood parameters."

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"SA has been reported to inhibit IKKbeta and has been shown to inhibit TNF-alpha in human mononuclear cells when DMXAA is combined with anti-CD14 antibodies or deacylated LPS."