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Luteolin inhibits NLRP3. 30 / 30
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"The study found that Luteolin inhibits neuroinflammation by regulating p38 MAPK activity in the spinal dorsal horn and blocking the activation of glial cells and NLRP3 inflammasomes."
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"Using a 3-dimensional cell co-culture system , we further demonstrated that luteolin could efficiently suppress NLRP3 expression via disruption of IL-17A signaling in inflamed colon tissue , which also indicates the pharmacological potential of luteolin and wedelolactone in treating IBD ."
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"Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID."
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"73 As a flavonoid compound, Luteolin inhibited LPS-induced liver inflammation by suppressing the production of inflammation-related genes TNF-α and IL-6.74 Luteolin alleviated macrophage infiltration and attenuated the kidney tissues damage caused by inflammation and oxidative stress, thus ultimately improving RF in a mouse model of MRL/lpr.75,76 Moreover, Yu reported that luteolin also inhibited the induction and activation process of NLRP3, thus alleviating podocyte injury.77 Oxidative stress stands as one of the contributory factors to renal diseases."
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"There were several publications that indicated that luteolin, luteoloside, and apigenin inhibited NLRP3 activation in rodents (Fan et al., 2014; Lv et al., 2019; Wang, X. et al., 2021); however, to the best of our knowledge, the present study is the first research that investigates the involvement of NLRP3 inhibition in the anti-gouty arthritis effects of luteolin, luteoloside, and apigenin."
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"Luteolin interfered in a similar manner to siNLRP3, inhibiting the formation of NLRP3 inflammatory small bodies and acting as an anti-apoptotic agent (Yu et al., 2019)."
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"Meanwhile , several previous studies have shown that luteolin ( Dong et al ., 2021 ; Lee et al ., 2021 ) , luteoloside ( Fan et al ., 2014 ; Wang , Z. et al ., 2021 ) , and apigenin ( Zhang et al ., 2014 ; Zhao et al ., 2019 ) could inhibit TLR4 signaling and NLRP3 expression ."
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"Besides inhibiting the formation of pro-inflammatory cytokines like IL-6, IL-1β, and TNF-α, and reducing the activities of NF-κB, luteolin can inhibit the activation of NLRP3 inflammasome, which is necessary for the maturation and secretion of IL-1β and IL-18."
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"It seems that these findings demonstrate that luteolin may be able to inhibit tumor cell growth by suppressing the NLRP3/IL-1 β signal axis [23]."
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"Luteolin robustly inhibited tumor growth by activating caspase-1/nod-like receptor thermal protein domain associated protein 3 (NLRP3)/gasdermin D (GSDMD)-mediated pyroptotic process."
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"Luteolin further inhibits the NLRP3 inflammasome signaling pathway by activating NRF2 to produce neuroprotection in mice with SAH[38]."
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"Luteolin supplementation reduced high fat diet induced NLRP3 inflammasome in adipose tissue of ovariectomized mice (M.N."
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"Luteolin treatment could inhibit the activation of neurons, glial cells, and NOD-like receptor protein 3 (NLRP3) inflammasomes in the dorsal spinal cord in the BCP mouse model."
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"In a recent study, luteolin was also found to inhibit in vitro and in vivo (C57BL/6J mice) the activation of NOD-, LRR- and pyrin domain-containing protein 3(NLRP3) inflammasome, therefore supporting luteolin’s role as an anti-inflammatory agent [77]."
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"Quercetin, luteolin and apigenin suppressed NLRP3 induction and/or caspase-1 activation in human umbilical vein endothelial cells, colitis model in mice and kidney injury model in rats ( Marquez-Flore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Luteolin inhibits NLRP3 inflammasome activation by preventing the interaction of NLRP3 with ASC."
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"This study proves that Lu can significantly reduce the increased production of NLRP3, ASC, Caspapse-1, IL-1β, p-IκBα, and p-NF-κBp65 caused by D-GaI/LPS."
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"Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression."
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"It is well documented that luteolin inhibits the activation of NOD-like receptor protein 3 (NLRP3) inflammasome by inhibiting TXNIP, Caspase-1, IL-1β and IL-18 and so on [89] ."
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"Mechanistically, luteolin can reduce ROS and expression of NLRP3 and other inflammatory mediators through the NF-κB pathway; however, it is a nonspecific inflammasome modulator as it also affects the expression of AIM2 (Chen et al., 2007; Zhang et al., 2018; Yu et al., 2019)."
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"And luteolin was reported to decrease production of ROS and expression of NLRP3, ASC, caspase-1, IL-18 and IL-1beta proteins in RAW264.7 cells, which were incubated with LPS."
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"Luteolin has been suggested to reduce inflammatory damage by downregulating NLRP3."
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"Based on the well-defined anti-oxidative effect of luteolin, we hypothesized that luteolin suppressed the activation of NLRP3 inflammasome through a ROS-dependent manner."
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"There were several publications that indicated that luteolin , luteoloside , and apigenin inhibited NLRP3 activation in rodents ( Fan et al ., 2014 ; Lv et al ., 2019 ; Wang , X. et al ., 2021 ) ; however , to the best of our knowledge , the present study is the first research that investigates the involvement of NLRP3 inhibition in the anti-gouty arthritis effects of luteolin , luteoloside , and apigenin ."
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"Luteolin supplementation at 50 or 100 µM for 24 h reduced NLRP3 and caspase-1 at mRNA and protein levels in glucose-treated podocyte [19] ."
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"Since TNF-α production is independent of the NLRP3 inflammasome, these results indicate that the luteolin specifically targets NLRP3 inflammasome activation.The amount of caspase-1 p20 (an autoprocess[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Q. Yu, et al investigated luteolin’s effect on apoptosis-related proteins including B-cell lymphoma-2 (Bcl-2), caspase-3 and caspase-9, and concluded that luteolin might inhibit NLRP3 inflammasome activated podocyte apoptosis [72]."
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"This result suggests that luteolin can suppress NLRP3 expression under a pro-inflammatory condition ."
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"Piperine, luteolin, and naringin inhibit the inflammatory response in rats by suppressing NF-κB and NLRP3 activation, thus reducing podocyte apoptosis [168, [183] [184] [185] ."
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"For example, quercetin, luteolin, and epigallocatechin gallate inhibit TXNIP/NLRP3 by reducing ROS in ECs (Wu et al., 2014)."
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