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Luteolin inhibits NLRP3. 14 / 14
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"Luteolin treatment could inhibit the activation of neurons, glial cells, and NOD-like receptor protein 3 (NLRP3) inflammasomes in the dorsal spinal cord in the BCP mouse model."
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"There were several publications that indicated that luteolin, luteoloside, and apigenin inhibited NLRP3 activation in rodents (Fan et al., 2014; Lv et al., 2019; Wang, X. et al., 2021); however, to the best of our knowledge, the present study is the first research that investigates the involvement of NLRP3 inhibition in the anti-gouty arthritis effects of luteolin, luteoloside, and apigenin."
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"Piperine, luteolin, and naringin inhibit the inflammatory response in rats by suppressing NF-κB and NLRP3 activation, thus reducing podocyte apoptosis [168, [183] [184] [185] ."
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"This result suggests that luteolin can suppress NLRP3 expression under a pro-inflammatory condition ."
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"There were several publications that indicated that luteolin , luteoloside , and apigenin inhibited NLRP3 activation in rodents ( Fan et al ., 2014 ; Lv et al ., 2019 ; Wang , X. et al ., 2021 ) ; however , to the best of our knowledge , the present study is the first research that investigates the involvement of NLRP3 inhibition in the anti-gouty arthritis effects of luteolin , luteoloside , and apigenin ."
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"We also demonstrated that luteolin inhibited NLRP3 inflammasome derived caspase-1 activation and IL-1beta secretion in J774A.1 macrophages upon diverse stimuli including ATP, nigericin, or silica crystals."
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"Q. Yu, et al investigated luteolin’s effect on apoptosis-related proteins including B-cell lymphoma-2 (Bcl-2), caspase-3 and caspase-9, and concluded that luteolin might inhibit NLRP3 inflammasome activated podocyte apoptosis [72]."
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"This study proves that Lu can significantly reduce the increased production of NLRP3, ASC, Caspapse-1, IL-1β, p-IκBα, and p-NF-κBp65 caused by D-GaI/LPS."
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"Meanwhile , several previous studies have shown that luteolin ( Dong et al ., 2021 ; Lee et al ., 2021 ) , luteoloside ( Fan et al ., 2014 ; Wang , Z. et al ., 2021 ) , and apigenin ( Zhang et al ., 2014 ; Zhao et al ., 2019 ) could inhibit TLR4 signaling and NLRP3 expression ."
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"And luteolin was reported to decrease production of ROS and expression of NLRP3, ASC, caspase-1, IL-18 and IL-1beta proteins in RAW264.7 cells, which were incubated with LPS."
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"Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID."
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"Taken together, these findings suggest that luteolin supplementation may suppress NLRP3 induction and activation process and thus potentially would be protective against NLRP3 mediated inflammatory diseases."
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"Quercetin, luteolin and EGCG reduced reactive oxygen species production and inhibited TXNIP and NLRP3 inflammasome activation, lead to the downregulation of IL-1beta expression."
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"Using a 3-dimensional cell co-culture system , we further demonstrated that luteolin could efficiently suppress NLRP3 expression via disruption of IL-17A signaling in inflamed colon tissue , which also indicates the pharmacological potential of luteolin and wedelolactone in treating IBD ."
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