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"We observed a marked increase in the level of PLK1 ubiquitination in the 2A mutant-transfected cells, consistent with our study that USP16 O-GlcNAcylation promotes its DUB activity."

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"In this paper, we report that O-GlcNAcylation of USP16 promotes its DUB activity toward uH2A and PLK1 and regulates USP16 localization through Crm1 (Fig. 6E)."