IndraLab

"14 However, the Lnc-ZFAS1-mediated mechanism in osteosarcoma still remains insufficient.Recently, the dysregulation of miRNAs has been verified closely correlated with tumors growth and metastasis,15 and accumulating studies have proved the crucial role of miRNAs in osteosarcoma, like miR-411-5p,2 miR-53916 and miR-4660.17 Liu W et al. suggested miR-140 could weak the protein stabilization of LSD1 mediated by targeting USP22 and facilitate the expression of p21 to block osteosarcoma progression.18 Interestingly, Wang J et al. have reported the suppressive influence of miR-520b on growth and metastasis in osteosarcoma."

"As a result, the GSK3β-dependent phosphorylation of LSD1 could induce the combination of USP22 and LSD1, thus leading to the deubiquitylation of LSD1 and enhancing its stability."