IndraLab

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OTUD6B activates Mice. 7 / 7
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"Otud6b deficiency inhibits PAH development in hypoxia mice models."
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"Furthermore, we found that human OTUD6B enhances type I IFN antiviral immune response in mice upon viral infection."
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"As shown in the figure, expressions of Calpain-1, Otud6b, and HIF-1α proteins were increased in hypoxia induced mice and HPAECs, while not seen in siOtud6b treated mice and HPAECs."
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"Thereafter, we intranasally infected OTUD6B-upregulated mice with VSV and found that IFN-β production was significantly increased in the lung tissue (Fig. 8B) and serum (Fig. 8C) of OTUD6B-upregulated mice compared with that in control vector-injected mice."
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"Consistently, ISG expression was higher in OTUD6B-upregulated mice (Fig. 8B), and less viral infection was detected in their lung tissue (Fig. 8D) and serum (Fig. 8E) than in control mice 3 days post infection."
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"When viral infection was extended to 10 days, survival results showed that OTUD6B-upregulated mice were more resistant to VSV infection than control vector-injected mice (Fig. 8F)."
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"Collectively, our data suggested that OTUD6B-upregulated mice possess a more potent type I IFN antiviral defense against VSV infection."
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