IndraLab

Statements

Tadalafil inhibits KCNH2. 3 / 3
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"Because the maximum soluble concentration of tadalafil (100 microM) produced only a 50.9% inhibition of the HERG current amplitude, the IC50 value for tadalafil could not be determined with the Hill equation."
15476742
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"It was shown that tadalafil also inhibits the hERG channel by concentration dependent manner with an IC 50 value of 100muM XREF_BIBR."
28150511
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"Since tadalafil blocks hERG1 K channels in concentration dependent manner, the cardiotoxicity prediction of the hit molecules was also tested."
28150511