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SB 203580 inhibits FOS. 5 / 5
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"Moreover, Western blot analysis confirmed that SB 203580 treatment abolished oxalate-induced up-regulation of p-38, p-MEK, p-ERK and c-fos (Figure 5I)."
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"C-Fos and c-Jun mRNAs were induced by TNF-alpha, and PD98059 (MEK inhibitor) and SB203580 (p38 inhibitor) abolished the up-regulation of c-Fos."
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"In this study, MEK (PD98059) and p38 MAPK (SB203580) inhibitors suppressed the IL-1beta-induced activation of c-Fos."
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"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."
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"Investigation of the effects of specific kinase inhibitors revealed that SB203580, a specific inhibitor for p38 MAPK, significantly blocked the upregulation of c-fos and the subsequent neuronal cell death."
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