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SB 203580 inhibits FOS. 8 / 8
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"SB 203580 strongly inhibited the induction of c-fos and c-jun by anisomycin and UV radiation."
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"C-Fos and c-Jun mRNAs were induced by TNF-alpha, and PD98059 (MEK inhibitor) and SB203580 (p38 inhibitor) abolished the up-regulation of c-Fos."
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"Moreover, Western blot analysis confirmed that SB 203580 treatment abolished oxalate-induced up-regulation of p-38, p-MEK, p-ERK and c-fos (Figure 5I)."
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"In this study, MEK (PD98059) and p38 MAPK (SB203580) inhibitors suppressed the IL-1beta-induced activation of c-Fos."
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"27,28 The selective p38 inhibitor (SB203580) suppresses the induction of both c-Fos and NFATc1, resulting in inhibition of the differentiation of monocytic precursors into osteoclasts."
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"Furthermore, treatment with SB203580, a specific inhibitor of p38 MAPK, significantly blocked the regulation of c-fos and neuronal cell death, whereas treatment with the p44/p42 MAPK inhibitors PD98059 and U0126 did not [29]."
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"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."
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"However, SB 203580 did not inhibit the induction of c-fos and c-jun in response to EGF; in fact, we consistently observed augmented c-fos and c-jun mRNA levels under these conditions."
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