IndraLab

Statements

Hydroxychloroquine inhibits cell growth. 12 / 12
| 12
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"CQ and HCQ were shown to induce apoptosis and inhibit ATLL cell growth both in vitro and in vivo."
| PMC
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"The efficacy of combining gemcitabine and docetaxel with other cell growth inhibitors, such as hydroxychloroquine and ADI-PEG20, in order to establish disease control is being explored in current clinical trials (NCT identifier : NCT03598595 and NCT03449901, respectively)."
33809018
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"We showed the phenotypic effects that HCQ inhibited cell growth, induced apoptosis and cell cycle arrest at G1/S transition in A549 and PC-9 cells, which was associated with inhibition of CDK2, CDK4, CyclinD1 and CyclinE, but up-regulation of p21 and p27 Kip1."
32001266
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"These observations agree with other reports showing that HCQ inhibits in vitro cell growth and in vivo tumor growth via induction of apoptosis."
27642552
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"Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis."
28433067
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"CQ and HCQ inhibit ATLL cell growth in vitro."
| PMC
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"Concurrent treatment with MRT68921 or HCQ plus EIPA or ML385 synergistically inhibited cell growth (Figures 6E and S7E–S7H)."
33740421
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"HCQ alone produced decreased cell growth and induction of caspase-dependent apoptosis in all S45F mutated DT cells tested but had no effect in T41A-mutated DT cells, confirming our previous results that S45F-mutated DT cell strains are highly dependent on autophagy instead of apoptosis."
30980399
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"The potency of hydroxychloroquine to inhibit cell growth significantly differed in P-gp over-expressing cells (L-MDR1) compared to the parental cell line (LLC-PK1) (IC50 : 82 +/- 10 microM for LLC-PK1; 427 +/- 16 microM for L-MDR1; p < 0.001)."
32992777
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"We found that HCQ inhibited cell growth, induced apoptosis, and altered cellular energy metabolism in all thee lines."
26134285
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"Invitro assays demonstrated that HCQ directly inhibited tumor cell growth in all the tested tumor cell lines."
33490900
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"In this study, we provided evidence that CQ and HCQ inhibit ATLL cell growth both in assays performed in vitro and in an in vivo mouse model of ATLL."
| PMC