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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 increases the amount of calcium(2+). 2 / 2

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"Coexpression of beta4 in heterologous cells slows activation kinetics of BK channel currents XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, generally increases the amount of Ca ++ and depolarization required for channel gating XREF_BIBR, XREF_BIBR, XREF_BIBR but see XREF_BIBR, and confers resistance to the specific peptide antagonists iberio- and charybdotoxin XREF_BIBR, XREF_BIBR."

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"History of seizures has been shown induce expression of more Ca 2+ sensitive BK channel splice variants, which may underlie the difference in paxilline efficacy between the two states."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...