IndraLab

Statements

USP14 activates Wnt. 6 / 9
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"In multiple myeloma cells, USP14 has been suggested to positively regulate Wnt/β-catenin signaling pathway because genetic inhibition of USP14 reduces intracellular abundances of β-catenin and Wnt ( X[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP14 can enhance the signal transduction of Wnt and beta-catenin."
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"Another research team discovered that USP14 deubiquitinated K63-linked polyubiquitin chains of Dvl, and USP14 inhibition could attenuate Wnt signal transduction [ 45 ]."
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"This suggests that regulation of Wnt signaling by Usp14 is controlled at the level of Dvl, rather than downstream components such as beta-catenin."
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"Attenuation of Wnt signal transduction by Usp14 inhibition."
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"Moreover, overexpression of USP14 in MM cell adhesion model could enhance the ability of cell adhesion by regulating Wnt signaling pathways, thereby promoting the CAM-DR in MM."
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