IndraLab

Statements

Ubiquitin activates TNFAIP3. 2 / 2
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"Although the AHD3 domain function is currently not described, AHD1 mediates binding with the ubiquitin editing enzyme Tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) and AHD4 mediates the interaction with OPTN ."
36898370
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"Accordingly, the RIPK1 deubiquitinating enzyme cylindromatosis (CYLD) is required for optimal necroptotic responses following TNFR1 ligation, whereas the ubiquitin modifying TNF alpha induced protein 3 (TNFAIP3; best known as A20) and LUBAC limit TNFR1 driven necroptosis by favoring RIPK1 ubiquitination."
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