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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Ubiquitin activates TNFAIP3. 1 / 1

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"Accordingly, the RIPK1 deubiquitinating enzyme cylindromatosis (CYLD) is required for optimal necroptotic responses following TNFR1 ligation, whereas the ubiquitin modifying TNF alpha induced protein 3 (TNFAIP3; best known as A20) and LUBAC limit TNFR1 driven necroptosis by favoring RIPK1 ubiquitination."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...