IndraLab

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"Accordingly, the RIPK1 deubiquitinating enzyme cylindromatosis (CYLD) is required for optimal necroptotic responses following TNFR1 ligation, whereas the ubiquitin modifying TNF alpha induced protein 3 (TNFAIP3; best known as A20) and LUBAC limit TNFR1 driven necroptosis by favoring RIPK1 ubiquitination."