IndraLab

Statements

USP17L2 activates SNAI1. 7 / 7
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"Inhibition of USP17 promotes SNAI1 degradation , thereby suppressing breast cancer invasion and metastasis ( 49 , 53 ) ."
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"Expression of Dub3 blocked Snail degradation mediated by the E3 ligases Fbxl14 and Fbxw1 and beta-TRCP 1 [XREF_BIBR]."
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"DUB3 (official symbol USP17L2) was shown to promote breast cancer invasion and metastasis via stabilizing Snail1 in a CDK4/6 activity-dependent manner ."
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"For example, Dub3 inhibition suppresses invasion and metastasis of breast cancer by promoting Snail1 degradation [ 23 ]."
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"43 However, Snail1 expression is only slightly higher in CRC tumor specimens than paired normal tissues (data not shown), suggesting that DUB3 might promote CRC progression primarily by stabilizing YAP1 rather than Snail1."
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"Moreover, the specific inhibitor of DUB3, WP1130, could suppress more than 50% of SNAIL-induced tumor cell migration, invasion and tumor growth, which provides an incredible therapeutic approach again[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"DUB3 also enhanced the stabilization of Snail ( Fig. 1 A)."
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