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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP17L2 activates SNAI1. 3 / 3

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"Inhibition of USP17 promotes SNAI1 degradation , thereby suppressing breast cancer invasion and metastasis ( 49 , 53 ) ."

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"DUB3 (official symbol USP17L2) was shown to promote breast cancer invasion and metastasis via stabilizing Snail1 in a CDK4/6 activity-dependent manner ."

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"Expression of Dub3 blocked Snail degradation mediated by the E3 ligases Fbxl14 and Fbxw1 and beta-TRCP 1 [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...