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(R)-rosmarinic acid inhibits JUN. 2 / 2
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"Rosmarinic acid reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity and protein levels in colon cancer HT-29 cells, repressed binding of the activator protein-1 (AP-1) in a nonmalignant breast epithelial cell line (MCF10A), and antagonized the stimulatory effects of TPA on COX-2 protein expression [XREF_BIBR]."
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"RANKL-induced p38 mitogen-activated protein kinase and the expression of nuclear factor of activated T cell, c-Jun, and c-Fos were inhibited by rosmarinic acid in bone marrow macrophages."
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