IndraLab

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USP35 increases the amount of SNAI1. 4 / 4
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"USP35 overexpression increased the Snail1 protein levels, whereas USP35 depletion decreased Snail1 protein levels."
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"Our results showed that overexpression of USP35 increased the protein level of Snail1 in these GC cells (Fig. 1C) in a dose-dependent manner (Fig. 1D), but USP35 did not change the mRNA level of Snail1 (Supplementary Fig. S4)."
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"As shown in Fig. 1L, MG132 treatment abrogated USP35 siRNA-induced Snail1 degradation, indicating that USP35 increased Snail1 expression by inhibiting proteasomal degradation."
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"The results revealed that wild-type USP35 (WT-USP35) dramatically increased Snail1 protein levels, whereas USP35-C450A did not affect Snail1 protein levels, indicating that the enzymatic activity of USP35 is necessary for its regulation (Fig. 1G)."
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