IndraLab

Statements

Proteasome inhibits USP14. 8 / 8
| 6 2
reach
"Validation of the protein interaction was achieved in primary cortical neurons (Figure 8B) and striatal neuronal cells (Figure 8C), corroborating that proteasome inhibition increased the association of endogenous USP14 with GABARAP compared with controls (lane 1, Figures 8B and 8C)."
31901637
reach
"Inhibition of USP14 by a small moleculeenhances proteasome activity and decreases misfolded proteins in mammalian cells following proteotoxic stress 11."
29581427
reach
"Activity probe assays with either the whole 26S proteasome or the 19S regulatory particle showed that the compound blocked the reaction of both USP14 and UCHL5 with haemagglutinin (HA)-tagged ubiquitin vinyl methyl sulfone (VMS)."
26852935
reach
"Activation of the proteasome activity, using an inhibitor of USP14, a deubiquitinase enzyme, inhibited OGD-induced cell death, and decreased calpain activity as determined by analysis of spectrin cleavage."
40095265
reach
"By displacing USP14, TRIM11 changes proteasome composition and suppresses both catalytic and non catalytic effects of USP14."
29581427
sparser
"Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is disrupted."
31901637
reach
"HA-UbVS pretreatment of auranofin could bind the HA tagged UbVS in the purified 26S proteasome, supporting that auranofin inhibits UCHL5 and USP14."
26097878
sparser
"Consequently, we next investigated the effect of proteasome inhibition or specific inhibition of the DUB USP14 on ROS production by macrophages."
31308397