IndraLab

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USP22 activates angiogenesis. 8 / 8
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"In addition, hypoxic preconditioning has been used as a tool for the regulation of angiogenesis, and hypoxic adipose stem cell-derived sEVs carrying a high abundance of USP22 promote angiogenesis and cutaneous wound healing through upregulation of lncRNA H19 [83]."
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"It has been reported that depletion of USP22 suppresses angiogenesis in mouse xenograft model of Non-small cell lung cancer [21], and promotes the effect of sorafenib in HCC [22]."
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"For instance, USP22, a ubiquitin hydrolase, enhances the proliferation, angiogenesis, and recurrence of NSCLC."
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"Knockdown of USP22 in an in vivo model was shown to decrease tumor angiogenesis, impair non-homologous DNA damage repair pathways and significantly improve the therapeutic efficacy of cisplatin."
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"Notably, USP22 knockout dramatically suppressed in vitro proliferation, colony formation; and angiogenesis, growth, metastasis of A549 and H1299 in mouse xenograft model, and significantly prolonged survival of metastatic cancer bearing mice."
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"Moreover, USP22 affected the function and interaction of different cell types in placental labyrinth vessels, while other studies have shown that USP22 knockout could significantly reduce tumour angio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data suggest that USP22 promotes angiogenesis in HCC partially related to VEGFA expression."
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"USP22 depletion decreased cell proliferation , migration , Vascular Mimicry ( VM ) formation , and angiogenesis ."
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