IndraLab

Statements

USP19 inhibits poly(I:C). 3 / 3
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reach
"Deficiency of USP19 increased serum cytokine levels after administration of poly(I:C) and LPS, and promoted inflammatory death caused by administration of poly(I:C) or LPS, or infection of Salmonella typhimurium."
31511519
reach
"Overexpression of USP19 inhibited poly(I:C)- and LPS-induced activation of NF-κB and IRF3, whereas USP19-deficiency had the opposite effects."
31511519
reach
"These results suggest that overexpression of USP19 inhibits poly(I:C)- and LPS-triggered IRF3 and NF-κB activation.We next examined the role of endogenous USP19 in regulation of TLR3/4-mediated signaling."
31511519