IndraLab

Statements

LDHA activates USP28. 5 / 5
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"Also, high glucose consistently triggered HK2 and LDHA expression and stimulated the USP28 and MYC axis in breast cancer cells (XREF_SUPPLEMENTARY)."
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"Silencing of LDHA significantly reversed induction of USP28 and MYC by epinephrine (XREF_FIG), while silencing of HK2 displayed no change on the effect of epinephrine (XREF_SUPPLEMENTARY)."
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"LDHA generating lactate enhances the USP28 signaling."
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"Following treatment with the LDHA inhibitor sodium oxamate, we found a reduction in USP28 stabilization induced by LDHA in a dose dependent manner (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Chronic stress induced epinephrine enhances LDHA dependent metabolic activity, which increases lactate and augments USP28 that serves to stabilize the MYC protein."
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