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USP48 activates gene expression. 1 / 1
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"It will be interesting to investigate whether USP48-dependent deubiquitination contributes to constitutive NF-κB activity in neurons and fine-tunes NF-κB dependent gene expression during early neuronal and synaptic development.Our study reveals a DUB-mediated nuclear mechanism that bidirectionally drives synapse remodeling: increasing the full-length USP48 expression reduces spine density, inhibits spine maturation, and markedly decreases functional synapse numbers and weakens synaptic efficacy in vivo, whereas decreasing USP48 expression has largely opposite effects."