IndraLab

Statements

TP53 activates USP10. 3 / 3
| 3
reach
"Hydroxylation of p53 on Pro359 increased its interaction with USP7 and USP10, leading to decreased p53 ubiquitination and increased p53 protein levels.P53 is also found a target of PHD1."
33894356
reach
"Downregulation of p53 abolished the inhibitory effect of USP10 on tumor growth (XREF_FIG and data not shown), confirming that USP10 inhibits cancer cell growth by stabilizing p53."
20096447
reach
"Since USP10 mediates the deubiquitination of p53, regulation of the deubiquitination activity of USP10 by Beclin1 likely plays an important role in tumor suppression."
24332849