IndraLab

Statements

TLR4 binds TNF and IL10. 3 / 3
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"Moreover, using the co-expression data of gene pairs, the data showed that the co-expression of IL1B and TNFA (under pathophysiological conditions), the co-expression of TNFA and IL4 (under physiological conditions), and the co-expression of TNFA and IL10 (under pathophysiological + physiological conditions) was strongly associated with TLR4 expression."
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"The results showed that TNFA ( d  = 0.61) and TLR4 ( d  = 0.34) were negatively associated with IL10 expression under basic conditions ( P  < 0.05)."
30816156
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"Failure otitis media recovery in TLR2 −/− and TLR4 −/− mice is associated with decreased TNF and enhanced IL-10 expression, suggesting that abnormalities of innate immunity may contribute to otitis media in humans and that innate immune pathways could be targets of otitis media therapy."
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