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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UCHL1 increases the amount of PHLPP1. 2 / 2

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"Further, UCHL-1 downregulated mTOR activity but promotes Akt activity by deregulating PHLPP1 expression."

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"It has been reported that aberrant UCH-L1 expression increases Akt signaling by decreasing the antagonistic phosphatase PHLPP1 level, and this effect is independent of proteasome but dependent on the UCH-L1 catalytic activity (Hussain et al. 2010)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...