IndraLab

Statements

UCHL1 increases the amount of PHLPP1. 2 / 2
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"Further, UCHL-1 downregulated mTOR activity but promotes Akt activity by deregulating PHLPP1 expression."
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reach
"It has been reported that aberrant UCH-L1 expression increases Akt signaling by decreasing the antagonistic phosphatase PHLPP1 level, and this effect is independent of proteasome but dependent on the UCH-L1 catalytic activity (Hussain et al. 2010)."
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