IndraLab

Statements

USP13 leads to the ubiquitination of BECN1. 4 / 4
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"Chemical Inhibition of the Deubiquitinating Enzymes USP10 and USP13 Causes Ubiquitination and Degradation of BECLIN 1."
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"For instance, USP10 and USP13 reduce Beclin-1 ubiquitination to prevent its degradation."
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"Inhibition of the Deubiquitinating Enzymes USP10 and USP13 Causes Ubiquitination of Beclin 1."
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"On the other hand, autophagy can be also inhibited blocking PI3KC3 complex formation; Spautin-1 indirectly inhibits the activity of VPS34 by proteosomal degradation of proteins that form VPS34 complexes through reduction of Beclin-1 deubiquitination mediated by USP10 and USP13 [120]."
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